Why We Chose Quatrefolic™ Folate (folic acid) for Methylation and Mood

If you’re tired, foggy, or flat, the issue may not be your diet—it might be how your body uses it. Quatrefolic™ is the active, methylated form of folate that bypasses genetic blockages and fuels critical processes like mood, detox, hormone metabolism, and heart health.

What Is Quatrefolic™?

Quatrefolic™ is a patented, bioavailable form of 5-Methyltetrahydrofolate (5-MTHF)—the natural, active form of folate used by your cells.

Unlike synthetic folic acid or food folate, Quatrefolic™ is ready for cellular use immediately - with no conversion required. That’s crucial for individuals with common gene variants like MTHFR and/or SHMT1, which can limit your ability to convert folate into its usable form.

It’s the most clinically studied 5-MTHF form available and is known for its superior stability, absorption, and biological activity.

What It Does (and Why It Matters for Men 40+)

Folate isn’t just about pregnancy. For men, it's a foundational nutrient for:

• Methylation, the process that controls detox, DNA repair, neurotransmitter balance, and more

• Mood regulation, by supporting serotonin, dopamine, and norepinephrine pathways

• Homocysteine clearance, reducing cardiovascular risk

• Estrogen metabolism, especially important during andropause

Quatrefolic™ works by:

• Delivering fully activated folate directly to your cells

• Supporting key neurological and hormonal pathways

• Reducing buildup of homocysteine (a cardiovascular and brain toxin)

• Enhancing mental clarity and emotional stability

| It’s not just about getting your B vitamins. It’s about giving your body the right form—so it can actually use them. |

What the Research Says

Quatrefolic™ has been studied for its role in:

• Reducing homocysteine levels more effectively than folic acid

• Supporting mood, cognition, and attention in adults with depression and cognitive decline

• Improving folate status in individuals with MTHFR gene mutations

• Enhancing reproductive health, DNA repair, and detoxification

One clinical study showed that Quatrefolic™ improved mood and motivation in individuals with major depressive disorder when added to traditional treatment. Other research shows it’s more effective than folic acid at raising blood folate and reducing inflammatory markers.

Why It’s in Our Morning Formula

We include 500 mcg of Quatrefolic™ in the HUSBAND Morning Formula—alongside methylated B12, B6 (P5P), magnesium glycinate, and betaine (TMG) to fully support methylation, mood, and energy metabolism.

These nutrients power your body’s most essential pathways: hormone balance, detox, neurotransmitter production, and DNA repair.

What to Expect

Most men notice:

• A lift in mental clarity and mood

• Reduced fatigue and emotional flatness

• Better stress resilience and focus

• Support for healthy blood pressure and heart health